منابع مشابه
Multiple Sulfur Acceptors Dock at IscS
Like a busy dock, the enzyme IscS offers a temporary berth to multiple protein vessels where they can load up with their cargo of sulfur atoms. The sulfur is then incorporated into essential biological structures such as the iron–sulfur clusters that catalyze oxidation–reduction reactions in the electron transport chain. Although the structure of IscS has been known for some time, it was not cl...
متن کاملTransfer of Sulfur from IscS to IscU during Iron-Sulfur Cluster Assembly
The cysteine desulfurase enzymes NifS and IscS provide sulfur for the biosynthesis of iron-sulfur proteins. NifU and IscU have been proposed to serve as template or scaffold proteins in the initial Fe/S-cluster assembly events, but the mechanism of sulfur transfer from NifS or IscS to NifU or IscU has not been elucidated. We have employed 35S-cysteine radiotracer studies to monitor sulfur trans...
متن کاملStructural Basis for Fe–S Cluster Assembly and tRNA Thiolation Mediated by IscS Protein–Protein Interactions
The cysteine desulfurase IscS is a highly conserved master enzyme initiating sulfur transfer via persulfide to a range of acceptor proteins involved in Fe-S cluster assembly, tRNA modifications, and sulfur-containing cofactor biosynthesis. Several IscS-interacting partners including IscU, a scaffold for Fe-S cluster assembly; TusA, the first member of a sulfur relay leading to sulfur incorporat...
متن کاملTransfer of sulfur from IscS to IscU during Fe/S cluster assembly.
The cysteine desulfurase enzymes NifS and IscS provide sulfur for the biosynthesis of Fe/S proteins. NifU and IscU have been proposed to serve as template or scaffold proteins in the initial Fe/S cluster assembly events, but the mechanism of sulfur transfer from NifS or IscS to NifU or IscU has not been elucidated. We have employed [(35)S]cysteine radiotracer studies to monitor sulfur transfer ...
متن کاملThe Iranian Journal of Cardiac Surgery President of ISCS Vice President of ISCS
Objective: OFFPump CABG surgery (opcab) is performing worldwide and the rate of coronary revascularization without CPB (cardiopulmonary Bypass) is growing significantly. The aim of this study is to evaluate the risk factors for early mortality after OPCABG. Methods: From April 2009 to April 2011, data were collected from a total of 920 patients who underwent OFFPump CABG. Variables that were re...
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ژورنال
عنوان ژورنال: PLoS Biology
سال: 2010
ISSN: 1545-7885
DOI: 10.1371/journal.pbio.1000353